Browsing by Author "Eikås, Karolina Di Remigio"

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    • Can the absolute configuration of cyclic peptides be determined with vibrational circular dichroism? 

      Eikås, Karolina Di Remigio; Monika, Krupová; Kristoffersen, Tone; Beerepoot, Maarten; Ruud, Kenneth (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-16)
      Cyclic peptides show a wide range of biological activities, among others as antibacterial agents. These peptides are often large and flexible with multiple chiral centers. The determination of the stereochemistry of molecules with multiple chiral centers is a challenging and important task in drug development. Chiroptical spectroscopies such as vibrational circular dichroism (VCD) can ...

    • A computational study of cyclic peptides with vibrational circular dichroism 

      Eikås, Karolina Di Remigio (Doctoral thesis; Doktorgradsavhandling, 2022-12-16)
      <p>Cyclic peptides are a class of molecules that has shown antimicrobial potential. These are complex compounds to investigate with their large conformational space and multiple chiral centers. A technique that can be used to investigate both conformational preferences and absolute configuration (AC) is vibrational circular dichroism (VCD). To extract information from the experimental VCD spectra a ...